Jaenicke, Elmar: Is activated hemocyanin instead of phenoloxidase involved in immune response in woodlice?
Gutenberg Open


Titelanzeige

Personen: Jaenicke, Elmar (Autor) 
Fraune, Sebastian (Autor) 
May, Sandra (Autor) 
Irmak, Pinar (Autor) 
Augustin, Rene (Autor) 
Meesters, Christian (Autor) 
Decker, Heinz (Autor) 
Zimmer, Martin (Autor) 
  
Titel: Is activated hemocyanin instead of phenoloxidase involved in immune response in woodlice?
  
Quelle: Developmental and comparative immunology. Bd. 33. H. 10. Amsterdam u.a. : Elsevier Science. S. 1055 - 1063
Erscheinungsjahr:    2009
ISBN / ISSN: 0145-305X ; 1879-0089
URL der Originalveröffentlichung doi:10.1016/j.dci.2009.05.005
  
Dokumentart:
Zeitschriftenaufsatz Zeitschriftenaufsatz
Sprache: Englisch
Open Access:
Personen der Universität:    Jaenicke, Elmar  In UnivIS suchen  ; Decker, Heinz  In UnivIS suchen 
Einrichtung: Institut für Molekulare Biophysik
DDC-Sachgruppe:    Biowissenschaften, Biologie
ID: 13375  Universitätsbibliothek Mainz
Hinweis:
Informationen zu den Nutzungsrechten unserer Inhalte Informationen zu den Nutzungsrechten unserer Inhalte
Abstract: In the Common woodlouse Porcellio scaber (Crustacea: Isopoda: Oniscidea), experimental immune challenge did not induce the expression of pro-phenoloxidase that, in most other invertebrates studied thus far, can be activated into phenoloxidase via an activation cascade upon immune challenge. Instead, Porcellio hemocyanin proved to exhibit catecholoxidase activity upon activation. However, none of the activating factors known from other invertebrates other than SDS-treatment resulted in activation of hemocyanin into a functional phenoloxidase in vitro. The distinct characteristics of isopod hemocyanin are reflected by the quaternary structure of the hemocyanin dodecamers that differs from that of other crustacean hemocyanins in that the two hexamers share a common 3-fold rotation axis and have an angular offset of 60 degrees against each other. Accordingly, the sequence of Porcellio hemocyanin can be distinguished clearly from other crustacean hemocyanins and in a phylogenetic analysis forms a cluster with other isopod and amphipod hemocyanins. We propose a peracarid-type hemocyanin that may have evolved in response to its required multiple functions in respiration and immune response, while phenoloxidase sensu strictu is lacking.
   
  
Verfügbarkeit prüfen:    Rechercheportal Mainz: 0145-305X/1879-0089
  KatalogPortal Mainz (inklusive FB 06): 0145-305X/1879-0089
  Elektronische Zeitschriftenbibliothek (EZB): 0145-305X oder 1879-0089
 


Im   
Impressum