Susewind, Moritz: Silica-coated Au@ZnO Janus particles and their stability in epithelial cells
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Personen: Susewind, Moritz (Autor) 
Schilmann, Anna-Maria (Autor) 
Heim, Julia (Autor) 
Henkel, Andreas (Autor) 
Link, Thorben (Autor) 
Fischer, Karl (Autor) 
Strand, Dennis (Autor) 
Kolb, Ute (Autor) 
Tahir, Muhammad Nawaz (Autor) 
Brieger, Jürgen (Autor) 
Tremel, Wolfgang (Autor) 
  
Titel: Silica-coated Au@ZnO Janus particles and their stability in epithelial cells
  
Quelle: Journal of materials chemistry : B. Bd. 3. H. 9. Cambridge : The Royal Society of Chemistry. S. 1813 - 1822
Erscheinungsjahr:    2015
ISBN / ISSN: 2050-750X
URL der Originalveröffentlichung doi:10.1039/C4TB02017K
  
Dokumentart:
Zeitschriftenaufsatz Zeitschriftenaufsatz
Sprache: Sonstige
Open Access:
Personen der Universität:    Henkel, Andreas  In UnivIS suchen ; Link, Thorben  In UnivIS suchen ; Fischer, Karl  In UnivIS suchen ; Strand, Dennis  In UnivIS suchen ; Kolb, Ute  In UnivIS suchen ; Brieger, Jürgen  In UnivIS suchen ; Tremel, Wolfgang  In UnivIS suchen 
Einrichtungen: Institut für Physiologische Chemie und Pathobiochemie
I. Medizinische Klinik und Poliklinik
Hals-, Nasen- und Ohren-Klinik und Poliklinik
Institut für Anorganische Chemie und Analytische Chemie
Institut für Physikalische Chemie
DDC-Sachgruppe:    Chemie
ID: 51448  Universitätsbibliothek Mainz
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Abstract: Multicomponent particles have emerged in recent years as new compartmentalized colloids with two sides of different chemistry or polarity that have opened up a wide field of unique applications in medicine, biochemistry, optics, physics and chemistry. A drawback of particles containing a ZnO hemisphere is their low stability in biological environment due to the amphoteric properties of Zn2 . Therefore we have synthesized monodisperse Au@ZnO Janus particles by seed mediated nucleation and growth whose ZnO domain was coated selectively with a thin SiO2 layer as a protection from the surrounding environment that imparts stability in aqueous media while the Au domain remained untouched. The thickness of the SiO2 layer could be precisely controlled. The SiO2 coating of the oxide domain allows biomolecule conjugation (e.g. antibodies, proteins) in a single step for converting the photoluminescent and photocatalytic active Janus nanoparticles into multifunctional efficient vehicles for cell targeting. The SiO2-coated functionalized nanoparticles were stable in buffer solutions and other aqueous systems. Biocompatibility and potential biomedical applications of the Au@ZnO@SiO2 Janus particles were assayed by a cell viability analysis by co-incubating the Au@ZnO@SiO2 Janus particles with epithelia cells and compared to those of uncoated ZnO. ER
   
  
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